Abstract
Sildenafil is a specific inhibitor of phosphodiesterase type 5 and is clinically used to treat erectile dysfunction and pulmonary artery hypertension because of its vasodilatation effect due to the relaxation of smooth muscle cells. In cardiac muscle, the cardioprotective effects of sildenafil have been reported. The effectiveness of sildenafil on skeletal muscle has been controversial: sildenafil reduces skeletal muscle fatigue, however, the atrophy of skeletal muscle by sildenafil is also reported. In addition, the effect of sildenafil on skeletal muscle in cellular levels has not been examined. In the present study, sildenafil effect on skeletal muscle cells was examined using mouse primary skeletal myoblasts. Sildenafil was effective to enhance the proliferation of the skeletal myoblasts.
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