Abstract
We analyzed signs and symptoms in 90 patients diagnosed with acute HIV infection in a community-based program that offered universal HIV-1 nucleic acid amplification testing. Forty-seven (52%) patients reported ongoing signs or symptoms at the time of testing. Another 25 (28%) reported signs or symptoms that had occurred during the 14 days before testing.
Highlights
We analyzed signs and symptoms in 90 patients diagnosed with acute HIV infection in a community-based program that offered universal HIV-1 nucleic acid amplification testing
Screening programs that rely on point-of-care HIV antibody testing will reliably identify persons with established infection, these tests fail to detect acute HIV infection (AHI) (1,5)
Previous studies focused on retrospective evaluation of AHI symptoms in persons diagnosed with early seropositive HIV infection (8,9) or cases identified by symptom-based AHI screening, the actual proportion of persons with AHI who are symptomatic at the time of testing remains unknown
Summary
CD4+ cell count, cells/μL, 435 (298–597) 435 (302–586) 448 (257–615) NS 424 (299–592) 445 (295–610) NS median (IQR). 69 patients (77%) reported signs or symptoms that met criteria of compatibility with AHI (Table 2). Onset of signs or symptoms compatible with AHI occurred at a median of 5 days (IQR 0–8, range –4 to 15 days) after the estimated date of infection. 70 (78%) of the 90 patients fulfilled criteria for having typical AHI and 20 (22%) did not (of the latter, 14 had only 1 sign or symptom, and 6 were asymptomatic). Patients with typical AHI had significantly higher viral loads compared with patients without (p
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