Abstract
IntroductionMalignant glioma is a brain tumor of very aggressive behavior and tissue invasion. A common polymorphic variant of GSTP1 (Ile105Val: A > G) has been associated with increased risk of various cancers including malignant glioma. Thus aim of this study was to address the association of GSTP1 Ile105Val to malignant glioma with respect to its clinico-pathological parameters. MethodThe frequency of genotype distribution among 166 malignant glioma cases and 210 healthy controls (cancer-free) from the same geographic region were evaluated by polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP). ResultsIn GSTP1 Ile105Val polymorphic sequence variation, significant differences of genotypic and allelic frequencies were observed among cases and controls (p < 0.05) with variant GG genotype as a strong risk factor of 5-fold to glima cases (p < 0.0001). The combined variant genotype (AG + GG) was found abundantly more in cases versus controls (63.8% > 39%: p < 0.05) with a 2.7 fold risk to Glioma cases. The per copy allele frequency of variant allele G (Val) was found to be 39% as against 21% in cases and controls respectively (P < 0.05). We also found a significant risk of >3-fold with combined variant allele (AG + GG) to smokers in cases (OR; 3.4, C: I; 2.0 to 5.8 and p < 0.05). ConclusionOur study shows that both allelic and genotypic variants of GSTP1 Ile105Val is strongly associated with higher risk to glioma in our population and further valine-related variant allele is connected with higher susceptibility to the disease in smokers.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call