Abstract
Objective: Platelet-activating factor [1—O—alkyl—2—acetyl—sn—glycero—3—phosphocholine; PAF] is a unique and novel signaling phospholipid which has pleiotropic reproductive properties in addition to platelet activation. PAF plays a significant role in spermatozoa motility, fertilization and implantation. PAF content in spermatozoa has a positive relationship to pregnancy outcome. Whereas, exogenous PAF has been used to enhance human fertilization potential, there are limited reports (Fertil Steril 2000;74(3S):S108; Amer J Obstet Gynecol 2001;184:1064) on the use of exogenous PAF to enhance pregnancy outcomes. The study objective was to determine the efficacy of treating spermatozoa with PAF prior to intrauterine insemination (IUI).
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