Significance of serum levels of inhibin B in women with polycystic ovary syndrome during controlled ovarian stimulation

Abstract

Objective To explore the dynamic variation of inhibin B(INHB) in patients with polycystic ovary syndrome(PCOS) in the course of controlled ovarian stimulation(COS). To analyze the correlation between the increment of serum INHB and the dosage of Gn and the number of oocytes in PCOS. Methods Immunohistochemistry was performed to assess the level of INHB in 90 patients with PCOS and 20 normal childbearing period women in the course of COS.We collected the blood samples of all the patients on the third day of the menstrual(day 3), the day start to administrate exogenous gonadotropin(Gn day), five days later of the Gn day(Gn5 day) and the day of HCG injection(HCG day), respectively. Results Compared with the control group, the serum level of INHB was higher in the PCOS group, regardless day3, Gn day, Gn5 day and HCG day, the difference was statistically significant(P<0.01). In the course of COS, the level of serum INHB in the tow groups was increased.In the PCOS group, the greater the ΔINHB(the growth of the serum level of INHB on Gn5 day), the less of the Gn dosage, and the more number of oocytes retrieved. Conclusion In the process of COS, the serum level of INHB has obvious change.The serum levels of INHB reduce after pituitary down-regulation, then increase after COS. Key words: Polycystic ovary syndrome; Inhibins