Significance of serum hs-CRP and BNP in the progression of chronic obstructive pulmonary disease

Abstract

Objective To investigate the changes and significances of serum high sensitive C reactive protein (hs-CRP) and B type natriuretic peptide (BNP) in the process of chronic obstructive pulmonary disease (COPD) to pulmonary heart disease (PHD) and heart failure (HF). Methods 250 COPD patients with different condition in our hospital from June 2015 to December 2017 were collected and divided into COPD group (102 cases), PHD group (76 cases), and HF group (72 cases) according to the disease progression, 60 health cases were collected as health control group (60 cases). Patients in heart failure group were classified into grade I group (n=16), grade II group (n=22), grade III group (n=20), and grade IV group (n=14) according to cardiac function. The serum hs-CRP and BNP were detected and compared among different groups, and ROC curve analysis was conducted among different groups. Results The contents of serum hs-CRP and BNP in COPD group [(16.2±6.6) mg/L, (182.6±68.4) ng/L], PHD group [(27.7±4.6) mg/L, (242.0±105.8) ng/L], and HF group [(58.8±35.6) mg/L, (297.5±235.6) ng/L] were significantly higher than those in health control group [(2.7±0.9) mg/L, (20.9±6.8) ng/L] (P<0.05), and those in PHD group were significantly higher than those in COPD group (P<0.05), those in HF group were significantly higher than those in PHD group and COPD group (P<0.05). The levels of hs-CRP and BNP of patients with heart failure in different cardiac function classification were significantly different (P<0.05); the higher the cardiac function classification was, the higher the serum hs-CRP and BNP levels of patients were. The results of ROC showed that the classification performance of hs-CRP was better in different case groups and different heart failure grade groups, and the classification performance of BNP in different heart failure grade groups were better, but had poor classification performance in different case groups. Conclusion Serum hs-CRP and BNP index were closely related to COPD progression and heart failure classification. The higher the indexes were, the more serious the disease was, which indicated that both hs-CRP and BNP were significant in the diagnosis of COPD state. Key words: High sensitive C reactive protein (hs-CRP); B type natriuretic peptide (BNP); Chronic obstructive pulmonary disease (COPD); Pulmonary heart disease; Heart failure