Significance of monitoring renal function and umbilical cord blood flow index of severe preeclampsia patients

Abstract

Objective To analyse and compare the renal function and umbilical cord blood flow index changes of early-onset and late-onset severe preeclampsia, to find effectiveindex to predict and evaluate the severity of severe. Methods preeclampsia analysis selected cases of severe preeclampsia (230 cases of early onset, 182 cases of late-onset), and 412 cases of normal singleton pregnancy were selected as the control group. Patients were divided into early and late onset preeclampsia with the point of 34 weeks. Collected and analyzed the related data of renal function, such as urea(BUN), creatinine(Cr) uric acid (UA), β2-microglobulin, α1-microglobulin and umbilical cord blood flow RI, PI, S/D value. Results BUN, UA, α1-microglobulin and umbilical cord blood flow RI, PI, S/D value of the early-onset preeclampsia group were higher than those of late-onset preeclampsiagroup. And the perinatal outcomes, such as delivery week, newborn weight, 1 min Apgar score, the percentage of stifle and transfer to NICU were statistically differenct(P<0.05). The receiver operating characteristic curve (ROC) was used to measure the area under the curve (maximum AUC=0.977) with UA as the detection index. Conclusions BUN, UA, α1-microglobulin and umbilical cord blood flow RI, PI, S/D value can be used as predictors of the onset gestational age and severity of severe preeclampsia patients, especially the prediction value of UA is highest. Key words: Early-onset severe preeclampsia; Renal function; Index of umbilical cord blood flow; Perinatal outcomes; ROC curve