Abstract
Objective:To explore the effect of induction chemotherapy on the treatment of locally advanced laryngeal cancer and hypopharyngeal cancer.Method: A retrospective analysis of 40 cases with advanced laryngeal cancer or hypopharyngeal cancer at the stage of Ⅲ-Ⅳb.Forty patients were randomly divided into two groups:treatment group(receive induction chemotherapy before surgery plus radiation therapy) and control group (receive surgery plus radiotherapy).During a five years followup, the therapeutic effect, the adverse treatment reactions, the survival rate and the larynx preservation rate were analyzed and compare between the two groups.Result:Twenty patients in the treatment group all received induction chemotherapy. After treatment, 3 patients with complete remission(CR), 14 patients with partial response(PR),2 patients in stable condition, and 1 patient with progression disease. The effective number of the treatment patients was 17 in the treatment group. The oneyear survival rate in the treatment group was higher than that in the control group(P<0.05),however, the 3-year and 5-year survival rate were similar in the two groups(P>0.05). The arynx preservation rate in the treatment and control group was 45%（9/20）and 15%（3/20）,respectively; and there was significant difference between the two groups(P<0.05).Conclusion:The Induction of chemotherapy has a better shortterm curative effect, which can alleviate clinical staging of the cancer, reduce tumor micro infiltration, increase the chance of patients with surgical opportunity and radiation therapy, and ultimately improve the outcome after treatment.
Published Version
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