Significance of Detection of Serum Immunoglobulin M Combined With High Sensitivity C-Reactive Protein in Early Diagnosis of Neonatal Septicemia

Abstract

Objective To evaluate the clinical significance of detection of serum immunoglobulin M (IgM) combined with high sensitivity C-reactive protein (hs-CRP)in neonates with septicemia. Methods From January 2006 to January 2009, 32 neonates with septicemia (gestational age of 37-41 weeks) were selected as septicemia group. Another 25 full-term neonates without bacterial infection were selected as control group. Informed consent was obtained from all participants. There had no significant differences of gestational week, birth weight, head circumference, and body length between two groups (P>0.05). The results of bacterial growth were observed by BACTEC 9050 blood culture system, and the level of immunoglobulin M and C-reactive protein were detected by nephelometry in two groups. Results There had significant differences of the level of serum immunoglobulin M and high sensitivity C-reactive protein between pre-therapy of septicemia group and control group [(0.56±0.11) g/L and (43.80±6.12) mg/L vs. (0.26±0.13) g/L and (8.35±2.39) mg/L] (P<0.05). There had significant differences of the level of serum immunoglobulin M and high sensitivity C-reactive protein before and after the treatment of septicemia group [(0.69±0.13) g/L and (7.59±4.44) mg/L vs. (0.56±0.11) g/L and (43.80±6.12) mg/L] (P<0.05). Conclusion The combined assay of serum immunoglobulin M and high sensitivity C-reactive protein are valuable for the early diagnosis of neonatal septicemia. Key words: immunoglobulin M; high sensitivity C-reactive protein; septicemia; neonate