Significance of CSF-LDH in various types of meningitis

Parul N Vekaria,Tarun Kotadia,Gauravi Dhruva,Jasmin H Jasani

doi:10.7439/ijbar.v6i3.1683

Abstract

The cerebrospinal fluid concentration of Lactate dehydrogenase (LDH) was studied in patients with pyogenic and tubercular meningitis. Significant increase in LDH level (P<0.001) were observed in the test group when compared to the control group. LDH may useful in differentiating viral from other meningitis. It may act as corroborative evidence of meningitis.

Highlights

USG and CT scan finding were noted.Cerebrospinal fluid (CSF) was obtain by lumber puncture and examined in detail including physical appearance, turbidity, presence of xanthochromia, cobweb, clot etc
Out of them 100 patients of all age groups and either sex of clinically suspected cases of meningitis were taken as test group
The physical, Biochemical and microscopic examination of CSF were done in all suspected meningitis to differentiate them in to pyogenic of non pyogenic including tubersulous and view group by the help of CSF examination including physical color, appearance, xanthochromia etc. chemical (Sugar, Protein) microscopic examination with estimation of CSF Lactate dehydrogenase (LDH) as mention in material and method

Summary

Aims and Objectives

X-ray, The purpose of this study was to establish early diagnosis and therapeutic value of CSF-LDH in bacterial and non bacterial meningitis. To evaluate the importance of CSF-LDH estimation as compared to other investigation in diagnosis of bacterial meningitis in adults as well as in children. To find out whether it is specific, superior and faster than other parameters in differential. USG and CT scan finding were noted.CSF was obtain by lumber puncture and examined in detail including physical appearance, turbidity, presence of xanthochromia, cobweb, clot etc. CSF microscopic examination including total cell count and differential count were done. Biochemistry analysis like (Sugar, Protein, Chloride, ADA and LDH) was done. To find out its usefulness in differential diagnosis of meningitis

Material and Methods

Findings

Discussion

Conclusion