Abstract
The discovery by the group of investigators in the epidemiology and pathobiology departments at the University of Washington’s School of Public Health in Seattle that specific antigenic components of Chlamydia pneumoniae are present in atherosclerotic lesions presents intriguing possibilities concerning the multifactorial nature of the pathogenesis of atherosclerosis. Starting in 1986, this group, headed by Professor Grayston, has been studying this relatively recently identified member of the Chlamydia genus. They quite recently found evidence that the specific antibodies to this pathogen can be identified serologically in the blood of many victims of coronary heart disease and/or myocardial infarction. This supports the results of Saikku et al reported in Lancet in 1988, which were confirmed by the University of Washington group led by Professor Grayston in 1991 and extended in a larger group of patients by Saikku and coworkers in 1992. Now they report very strong evidence that the organism is lurking in the lesions …
Published Version
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