SIGNIFICANCE OF BLOOD BIOCHEMICAL INDICES IN CHILDREN WITH ASSOCIATED INJURY

Abstract

Clear concept of pathobiochemical processes caused by severe injuries can be beneficial for optimization of treatment of sufferers with associated injuries. Biochemical investigations acquire special actuality in childhood in conditions of a growing organism. Aim. To assess the blood biochemical indices in children with associated injury. Materials and methods. One hundred and four patients after traffic accidents were admitted to pediatric surgery hospital and observed. Craniocerebral injury (CCI) was diagnosed in 72,1% of sufferers, abdominal injuries – in 61,5%, thoracic injuries – 26%, fractures – 53,8%. Laboratory investigations included bulk blood test, biochemical blood test: glucose, creatinine, urea, total amylase, alanine (ALT) and asparaginic transferases (AST), total bilirubin, whole protein and albumin in blood serum. These analyses were investigated on the days 1, 4, 7 and 10 after the accident. Results. The associated injury was stated to have a negative effect on carbohydrate, protein and pigment metabolism, to be accompanied by functional hepatic and pancreatic disorders increasing by the days 3–5 of traumatic disease and to be characterized by elevated activity of blood aminotransferases and α-amylase as well as disturbances of functional kidney status. CCI, as a component of associated injury, had unfavourable effect on restoration of the disturbed functions. Conclusion. Hypoalbuminemia, hypoproteinemia, increased ALT activity are prognostically unfavorable criteria for associated injury. These indices acquire special significance when CCI is one of the components of associated injury.