Abstract
Objective To investigate the role of ATRX and P53 gene mutations in the classification of diffuse glioma in Chinese. Methods A total of 89 cases of diffuse astrocytoma (IDH mutation) or diffuse astrocytoma (IDH wild type) and all levels of oligodendroglioma from 2016 to 2017 were collected, and detected the expression of ATRX protein and over expression of P53 protein by immunohistochemistry, and analyzed their expression in different types of diffuse gliomas. Results The ratio of ATRX loss expression in diffuse astrocytoma (IDH mutation) (17/24) was higher than that in oligodendrogliomas (3/16), P<0.01; the ratio of P53 over expression in diffuse astrocytoma (IDH mutation) (15/24) was higher than that in oligodendrogliomas (1/16), P<0.01; the ratio of ATRX loss expression in diffuse astrocytoma (IDH mutation) (71%, 17/24) was higher than that in diffuse astrocytoma (IDH wild) (41%, 20/49), P<0.05. Conclusions ATRX and P53 mutation is one of the molecular genetic characteristics of diffuse astrocytoma (IDH mutation), which may be contributed to diagnose diffuse astrocytoma. Key words: Diffuse glioma; Tumor suppressor protein P53; Alpha thalassemia/mental retardation syndrome-X
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