Relationship between IDH1 mutation and clinic pathologic features in human gliomas

Abstract

Objective To evaluate the frequency and Clinic Pathologic Features of isocitrate dehydrogenase 1 (IDH1) gene mutation in different pathological types and different WHO grades of glioma patients. Methods The frequency of IDH1 gene mutation was detected by immunohistochemistry in 76 patients with different pathological types and WHO grades of glioma specimens, and the pathological type, WHO grades and patient age of IDH1 gene mutation were analyzed. Results Among 76 glioma patients, IDH1 gene mutation was found in 37 patients, the total mutation rate was 48.68%. Mutation rates from high to low were as below: Diffuse Astrocytoma (71.43%), Anaplastic Oligoastrocytoma (71.43%), Oligodendroglioma (66.67%), Oligoastrocytoma (66.67%), Anaplastic Astrocytoma (63.64%), Glioblastoma (34.62%). Among Diffuse Astrocytoma, Oligoastrocytoma, Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma and Glioblastoma patients, IDH1 genotype patients were generally younger than wild-type ones,the difference was statistically significant. Conclusion The frequency of IDH1 gene mutation is high in WHO grade Ⅱ and Ⅲ gliomas. IDH1 gene mutation plays important role in the development and progression of glioma. Key words: Glioma; Isocitrate dehydrogenase 1 gene; Mutation; Pathological type