Abstract
Significance of Antiphospholipid Antibodies in Essential Cryoglobulinemia: A Case Report and Review of Literature
Highlights
Mixed cryoglobulinemia (MC) is a complex disorder with a broad spectrum of clinical manifestations
Type II and type III, designated “mixed cryoglobulinemia”, has immuno complexes formed of a monoclonal or polyclonal IgM rheumatoid factors (RF) and polyclonal IgG
In 1990s it was established that most of these essential MC are associated with chronic hepatitis C virus (HCV) infection [2,3]
Summary
Mixed cryoglobulinemia (MC) is a complex disorder with a broad spectrum of clinical manifestations. We know that MC is associated with clinical situations that generate large amounts of IgG and immune complexes, including chronic autoimmune diseases such as systemic lupus erythematosus, Sjögren’s syndrome [4] or infections such as HCV and HIV infections.
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