Abstract
Aflatoxins B1, B2, G1, and G2 are highly toxic and carcinogenic secondary metabolites produced by Aspergillus flavus and Aspergillus parasiticus fungi. Aflatoxin B1 (AFB1) has been recognized as one of the most potent chemical carcinogens [1]. The acute toxicity, mutagenicity, and carcinogenicity of aflatoxins are associated with the presence of the 8,9 double bond and the terminal cyclopentanone ring (Figure 1). The order of the severity of acute and chronic toxicity is B1> G1> B2> G2, reflecting the role of the 8,9 double bond and the greater potency associated with the cyclopentanone ring of the B series [2].
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