Abstract
Seasonal outbreaks of cutaneous and renal glomerular vasculopathy (CRGV) have been reported annually in UK dogs since 2012, yet the aetiology of the disease remains unknown. The objectives of this...
Highlights
Cutaneous and renal glomerular vasculopathy (CRGV) is a disease of unknown aetiology variably associated with clinically relevant acute kidney injury (AKI)
Two Kennel Club (KC) breed-groups – gundogs and hounds were between 9 and 10 times more likely to be diagnosed with CRGV than terriers, while no toy dogs were diagnosed with the disease
The results of this study suggest that gundogs and hounds, have an increased risk of developing CRGV in the UK, while toy dogs and terriers appear to be the breed-groups least at risk
Summary
Cutaneous and renal glomerular vasculopathy (CRGV) is a disease of unknown aetiology variably associated with clinically relevant acute kidney injury (AKI). A previous case series (Holm and others 2015) indicated that cases presenting with skin ulceration typically progress within a range of [1,2,3,4,5,6,7,8,9] days (median 4 days) to develop AKI, azotaemia and in many confirmed cases, acute renal failure with oligo-anuria. Mortality rate in those cases that progress to oligo-anuria is high with a confirmatory diagnosis of CRGV only being made at post-mortem examination. Suspected cases have been identified that appear less severely affected and where renal recovery may occur, lack of a viable ante-mortem diagnostic test precludes definitive diagnosis in these cases
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