Abstract
The regulation of cardiac homeostasis is especially important in a non-regenerative cell type like the cardiomyocyte. Suppression of hypertrophic and apoptotic signaling pathways is of critical importance for the regulation of cardiac homeostasis. The ubiquitin-proteasomal system is a highly conserved cascade which plays an essential role in regulating a diversity of systems through the rapid post-translational protein modification leading to changes in protein signaling and stability. This system is also important in the cardiovascular system, and in particular, in the heart. In this review, we discuss what is known of the regulation of cardiac homeostasis by the E3 ubiquitin ligase Mule, who’s substrates include the highly characterized proteins p53, myc, and Mcl-1, which are known to play important roles in the regulation of apoptosis and cardiac hypertrophy in heart failure. Mule is also known to play various roles in the regulation of chromatin dynamics, especially following the detection of DNA double strand breaks, and the activation of the DNA damage response. Accordingly, Mule appears to play an indispensable role in the regulation of cardiac homeostasis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
