Abstract
Redox Signaling and the Cardiovascular and Skeletal Muscle System.
Highlights
Overburden of oxidative stress has been associated with atherosclerosis, ischemic heart disease, hypertension, cardiomyopathies, cardiac hypertrophy, heart failure, and skeletal muscle diseases such as muscular dystrophy and sarcopenia
Similar results were obtained when human cardiomyopathy heart homogenate samples were investigated. These results strongly suggest that oxidative stress may exacerbate the development of heart failure
The authors showed that a significant increase in the levels of oxidized proteins coupled with impaired antioxidant defenses in essential hypertensive patients might be a potential cause for cardiac dysfunction
Summary
Editorial Redox Signaling and the Cardiovascular and Skeletal Muscle System The role of reactive oxygen species (ROS) in skeletal, cardiac, and vascular dysfunctions has been under investigation for decades. Over the last decade advanced in vitro and in vivo approaches have significantly improved our understanding of the role of oxidative stress in cardiovascular and skeletal muscle diseases.
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