Abstract
The ability of natural killers to split biological signal (dissociation of cytotoxic and interferon-producing activities) is the main precondition of the involvement of the natural cytotoxicity system in endogenous biological retranslation. Dissociation of the primary functions of natural cytotoxicity effectors is provided by enhanced interferon production against the background of decreased cytotoxicity of natural killers, or by enhanced natural cytotoxicity against the background of almost complete inhibition of interferon production. Dissociation of the primary functions of natural killers is a physiological phenomenon; it is induced and maintained by factors, which are not directly connected with induction or suppression of the immune response.
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