Abstract
In this pilot study, we report the use of a novel, patented biophysical technology, which enables intranuclear access and cell nucleus stimulation, via the signal of the biophysically activated regulative molecule 31 (RM31). RM31 is the name of an isolated natural molecule found in the human body and is involved in many cellular mechanisms. We used a specific low electromagnetic field frequency to activate the RM31 molecule, which leads to specific signal transduction, to investigate the effect of telomerase activity in HL60 cancer cells. Our results revealed a dramatic inhibition in telomerase activity, a 99.5% decrease within 72 hours, with avoidance of subsequent reactivation, due to the simultaneous inhibition of human telomerase reverse transcriptase (hTERT).
Highlights
Cancer develops when normal cells change into tumor cells
Our results showed a consistent decrease of telomerase activity: a 99.5% decrease within 72 hours after treatment with regulative molecule 31 (RM31) + biophysical device (QO) compared to treatment with RM31 alone (Figure 1 and Table 1)
Our results showed that human telomerase reverse transcriptase (hTERT) mRNA expression for the samples treated with RM31 and the Quantum One (QO) laboratory device could no longer be determined at any of the time points (Table 4), suggesting a complete inhibition of hTERT, as glyceraldehyde 3-phosphate dehydrogenase (GAPDH) mRNA was successfully determined for these samples, indicating that the lack of a signal for hTERT was not due to a technical problem
Summary
Cancer develops when normal cells change into tumor cells. This occurs via a multi-stage process that progresses from a pre-cancerous lesion to a malignant tumor [1]. These changes are the result of the interaction between a person's epigenetic factors and three categories of external agents, including physical, chemical, or biological carcinogens. Smoking, drinking alcohol, eating an unhealthy diet, physical inactivity, and air pollution are the major risk factors for developing cancer [1]. The properties of a cell are passed on to the generation via both genetic and epigenetic routes [2]. Genetic information is encoded in the DNA sequence while epigenetic information is defined by DNA and chromatin modifications (DNA methylation or methylation, phosphorylation, acetylation, and ubiquitination of histone cores)
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