Sigara içiminin kronik hepatit B ve C histopatolojisi üzerine etkisi

Abstract

Background and aims: The possible hepatotoxicity of cigarette smoke has been recently discussed in epidemiological and experimental studies. This study examined the possible relationship between smoking and degree of liver fibrosis in patients with chronic hepatitis B and chronic hepatitis C. Material and methods: The study was performed on a group of 55 patients with chronic hepatitis B and of 51 patients with chronic hepatitis C in whom the diagnosis had been confirmed by liver biopsy. Patients were evaluated according to age, gender, number of cigarettes smoked, alcohol consumption, scores of HAI and fibrosis on the liver biopsy. Results: Thirty-two (58%) chronic hepatitis B and 22 (43%) chronic hepatitis C patients were smokers. In patients with chronic hepatitis C, smokers had high HAI score (0.013) and fibrosis (0.042) on liver biopsy compared with non-smokers. Such results were not found in patients with chronic hepatitis B (for HAI score p: 0.456 and for fibrosis p: 0.084). If patients with no history of alcohol consumption are taken as a separate group, there were similar results in each group (in patients with chronic hepatitis B, p value for both HAI score and fibrosis was >0.05, and in patients with chronic hepatitis C, p value for HAI score and fibrosis was 0.053 and 0.042, respectively). Conclusions: Smoking increases the severity of hepatic lesions in patients with chronic hepatitis C but in not in those with chronic hepatitis B.