Abstract

The clinical significance of vancomycin-resistant Enterococcus (VRE) infections has been debated for many years. An article in this issue of the journal by Dubberke and co-workers (Vancomycin-resistant enterococcal bloodstream infections on a hematopoietic stem cell transplant unit: are the sick getting sicker?) addresses this question. This is a retrospective cohort study of patients with hematologic malignancies and recipients of hematopoietic stem cell transplant (HSCT) who developed nosocomial VRE bloodstream infections (BSIs) over the course of almost 7 years at Barnes-Jewish Hospital. Data regarding VRE infections in this highly immunosuppressed population has been sparse,1, 2 and this paper, reporting the characteristics and outcomes of 60 patients who suffered 68 VRE BSIs, represents the largest published series of VRE BSIs in this population to date.3

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