Short‐term feeding effects of origanum syriacum crude extract on blood constituents in rats

Abstract

This study was carried out to investigate the effect of the whole crude extract of Origanum syriacum on different biochemical parameters in blood using animal model. The aerial parts of Origanum syriacum were extracted with petroleum ether, chloroform, methanol and water, all these extracts were combined to prepare the whole extract then administrated orally in two doses 100mg/kg and 400mg/kg. The results obtained indicate that the extract showed a significant decreasing effect on low density lipoprotein (LDL‐cholesterol), triglycerides and glucose in both doses, while a non significant increase of urea and high density lipoprotein (HDL‐cholesterol) was observed as compared to normal saline treated controls. This study showed that the whole extract of Origanum syriacum possess a potential pharmacological activity in lowering the major lipid profile parameters in which we have reported for the first time.This work is sponsored by Al‐Zaytoonah University of Jordan.