Short-term efficacy of iodine-125 radioactive seed implantation therapy for hypoxic tumors

Abstract

Objective To study the short-term efficacy of computed tomography (CT)-guided iodine-125(125I) radioactive seed implantation in the treatment of hypoxic tumors. Methods Twenty-two patients treated with 125I radioactive seed implantation in our department from 2014 to 2016 were divided into hypovascular tumor group (hypoxic group, n=12) and hypervascular tumor group (non-hypoxic group, n=10) based on the hemodynamics of solid tumor evaluated by color Doppler ultrasound. The enhanced CT images were loaded to the three-dimensional particle implantation planning system for preoperative planning. After 125I radioactive seed implantation, the D90 for target volume was verified to be 106-128 cGy. Treatment outcomes were evaluated according to the World Health Organization criteria at 1-3 months after surgery. Results In all the patients, the overall response rate was 82% at 3 months after surgery. There were no significant differences in response (complete response+ partial response) rates at 1, 2, or 3 months after surgery between the hypoxic group and the non-hypoxic group (P=0.840, 0.696, 0.840). Conclusions In the treatment of solid malignant tumor, 125I radioactive seed implantation can overcome the resistance of hypoxic tumor to radiotherapy in vitro and achieve satisfactory short-term efficacy. Key words: Iodine-125 radioactive seed; Hypoxic tumor; Short-term efficacy