Abstract
To investigate the effect of buserelin on gonadal structure and function in adult male rats. Twenty-four adult Wistar male rats were divided into three groups: two treated groups and controls. The first and second treated groups received 300 (low dose) and 500 (high dose) µg/kg buserelin, respectively, and the control group received normal saline. All groups were treated subcutaneously for five days. The seminiferous tubular epithelial thickness was significant decreased in the treated groups compared with those in the control. There was a significant increase in apoptotic cell death in high dose treated group compared with low dose treated and control groups. No significant difference in serum testosterone level was observed after one month in the three groups. Buserelin induces apoptotic cell death and decreased diameter and epithelium thickness of seminiferous tubules in the adult rat testes.
Highlights
As a very important phenomenon in nature, reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis in all vertebrates[1]
Testosterone levels in the treated groups were compared to the control group
Seminiferous tubule diameter and seminiferous epithelial thickness were assessed in the testicular morphometric
Summary
As a very important phenomenon in nature, reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis in all vertebrates[1]. This axis is a blend of both neural and endocrine tissues that function as a coordinator unit in the regulation of fertility[2]. In the anterior pituitary gland, the gonadotropic cells act as moderators between the GnRH signal and production of steroid hormone by the gonads. Binding of GnRH to the receptors can start up intracellular events within the gonadotropes. These events lead to the synthesis and release of gonadotropins, Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH). GnRH receptors are locally expressed in the testes, brain, and placenta of mammals[6,7]
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