Short-Term and Long-Term Efficacy and Safety of Pemetrexed and Tislelizumab in Advanced Epidermal Growth Factor Receptor Tumor Protein 53 Co-Variant Lung Adenocarcinoma

Abstract

We attempt to study the short-term and long-term efficacy and safety of pemetrexed combined with tislelizumab in advanced epidermal growth factor receptor tumor protein 53 co-variant lung adenocarcinoma. The purpose is to explore the application effect of chemotherapy combined with immunotherapy in advanced epidermal growth factor receptor tumor protein 53 co-variant lung adenocarcinoma and provides reference for clinical work. We randomly selected 66 patients with advanced epidermal growth factor receptor+tumor protein 53 co-variant lung adenocarcinoma received from July 2019 to June 2021, then divided them into control group (n=33) and observation group (n=33). Treated control group with chemotherapy alone (pemetrexed), treated observation group chemotherapy combined with immunotherapy (pemetrexed+tislelizumab). Evaluated the short-term and long-term efficacy and safety of both groups, and checked the changes of immune indexes before and after treatment in both groups. In the comparison of short-term efficacy, observation group had higher disease control rate and objective remission rate than control group (p<0.05); but in the comparison of long-term efficacy, observation group had remarkably higher median disease progression-free survival than control group (p<0.05); both groups had no obvious difference in adverse reactions rate (p>0.05); in the comparison of immune indicators, observation group had higher cluster of differentiation 3+, cluster of differentiation 4+, cluster of differentiation 4+/cluster of differentiation 8+ and natural killer cells activities in T cell subsets than control group, but lower cluster of differentiation 8+ in T cell subgroup than control group (p<0.05). Chemotherapy combined with immunotherapy (pemetrexe+tislelizumab) application is effective and safe in advanced epidermal growth factor receptor+tumor protein 53 co-variant lung adenocarcinoma treatment, can prolong the survival period of patients, has good safety and will not have a great impact on immune indicators level.