Clinical immunotherapy with Chinese and western medicine for oral lichen planus and its adverse reactions

Abstract

Objective To study and analyze the effect of clinical immunotherapy with Chinese and western medicine for oral lichen planus and its adverse reactions. Methods 110 patients with oral lichen planus were selected from our hospital as a control group and were treated with levamisole. And another 110 patients with oral lichen planus were selected as an observation group and treated with levamisole and Chinese medicine for immunotherapy. The 8 weeks short-term efficacy and 1 year long-term efficacy were observed in both groups. The levels of interleukin 6 and 8 and tumor necrosis factor alpha were observed before and after the treatment. Results The short-term efficacy was 94.5% (104/110) in the observation group and 83.6% (92/110) in the control group (χ2=3.87, P<0.05). The long-term efficacy was 91.8%(101/110)in the observation group and 66.4% (73/110)in the control group (χ2=7.24, P<0.05). The levels of interleukin 6 and 8 and tumor necrosis factor alpha were (1.03±0.14), (12.09±2.04), and (12.46±2.10) in the observation group and were (2.29±1.04), (15.34±3.23), and (15.39±2.34) in the control group, with statistical differences (P<0.05). After 8 weeks’ treatment, 13 cases got adverse reactions in the control group and none in the observation group, with a statistical difference. Conclusions Clinical immunotherapy with Chinese and western medicine for oral lichen planus is effective and can speed up the patients’ recovery of oral mucosa. Key words: Clinical immunity; Chinese and western medicine; Oral cavity; Lichen planus