Short Review on Thiazole Derivative

Abstract

Thiazole is aromatic, heterocyclic organic compound that have five membered molecular ring structures C3H3NS. Thiazole was first described by Hantzch and Weber in 1887. Prop confirmed its structure in 1889. The numbering of thiazole starts from sulphur atom. Numerous reports have appeared in the literature which highlights their chemistry and pharmacological uses. There is larger Pi-electron delocalization in thiazoles as compared to corresponding oxazoles and hence have greater aromaticity which is evidenced by the chemical shift of the ring protons in proton NMR spectroscopy indicating strong diamagnetic current. Mostly researches have maintained their interest in nitrogen and sulphur containing heterocyclic compounds through decades of historical development of organic. This paper aims to review the antimicrobial activities of thiazole during the past decades. Keywords: Thiazole, Heterocyclic compounds, Oxazoles Biological activities,