Short Communication: Net Uptake of Nonesterified Long Chain Fatty Acids by the Perfused Caudate Lobe of the Caprine Liver

Abstract

The objective was to determine whether net uptake of various nonesterified long chain fatty acids differs in the caprine liver. Caudate lobes were isolated from four mature goats and perfused (1 ml/min×g wet tissue) with buffer containing 0.3mM of each palmitic, stearic, oleic, linoleic, linolenic, eicosapentaenoic, and docosahexaenoic acids. The amount of fatty acid in the perfusate decreased over time for all fatty acids with the exception of stearic acid. There was no net uptake of stearic acid, which was significantly different from all other fatty acids examined, with the exception of oleic acid. Net hepatic uptake of oleic acid was numerically, but not significantly lower than palmitic, linoleic, linolenic, eicosapentaenoic, and docosahexaenoic acids. It was concluded that net uptake of fatty acids was similar for all fatty acids tested with the exception of stearic acid.