Abstract
[Figure: see text].
Highlights
In 1722 hypertensives recruited for the European Lacidipine Study on Atherosclerosis and treated with atenolol or lacidipine (±additional drugs) during 4 years, we evaluated the long-term reproducibility of dipping, nondipping, extreme dipping, and reverse dipping, an information of key relevance for defining the prognostic impact of these blood pressure (BP) phenotypes
Available studies on the prognostic value of nighttime BP phenotypes have one feature in common, that is, either in untreated cohorts or in cohorts of patients under antihypertensive drug treatment, the nighttime BP phenotype was identified by one ambulatory BP monitoring only, which means that no information could be made available on the consistency of any given nighttime BP phenotype over time
This finding is relevant to the studies on the prognostic value of nighttime BP which have been based on a follow-up of several years during which data from only one ambulatory BP monitoring were available
Summary
In 1722 hypertensives recruited for the European Lacidipine Study on Atherosclerosis and treated with atenolol or lacidipine (±additional drugs) during 4 years, we evaluated the long-term reproducibility of dipping, nondipping, extreme dipping, and reverse dipping, an information of key relevance for defining the prognostic impact of these blood pressure (BP) phenotypes. Available studies on the prognostic value of nighttime BP phenotypes have one feature in common, that is, either in untreated cohorts or in cohorts of patients under antihypertensive drug treatment, the nighttime BP phenotype was identified by one ambulatory BP monitoring only, which means that no information could be made available on the consistency of any given nighttime BP phenotype over time This is an important limitation because in the few studies that have addressed this issue, the dipping and nondipping phenotypes were found to be poorly reproducible, that is, that a noticeable fraction of dippers at the first ambulatory BP monitoring became nondippers at the second one and vice versa.[16,17,18,19,20]. The present investigation, based on the analysis of the data collected in the ELSA trial, was aimed at providing information on the long-term reproducibility of nighttime blood pressure (BP) phenotypes as well as on the effects of antihypertensive treatment on these phenotypes
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