Abstract
The aerial part of Dittrichia viscosa yielded two sesquiterpenes, isocostic acid ( 1) and ilicic acid ( 2), on multigram scale. These acids are appropriate starting materials for short and facile syntheses of α-eudesmol ( 5) and cryptomeridiol ( 6), natural products featuring anti-Alzheimer and anti-spasmodic properties. Compounds 5 and 6 were obtained in three steps in overall yields of 70% and 52%, respectively.
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