Abstract
Most, if not all, enzymes are capable of catalyzing physiologically irrelevant secondary reactions-termed 'promiscuous' reactions-in addition to the reactions that they have evolved to catalyze. Promiscuous activities can provide the starting point for evolution of new enzymes, both in nature and in the hands of protein engineers. Recent work suggests that the universe of promiscuous activities available in nature is enormous. New high-throughput approaches have significantly advanced our ability to identify promiscuous activities, setting the stage for synthetic biology efforts to construct novel pathways using catalysts derived from promiscuous enzymes via directed evolution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
