Abstract
We propose and experimentally demonstrate a shift-multiplexing complex spectral-domain optical coherence tomography (shift-multiplexing CSD-OCT) method, in which the maximum detection depth of SD-OCT can be greatly extended by incorporating the shift-multiplexing of detection positions with CSD-OCT. The tomographic imaging with twofold or threefold microscopic slides as the target sample is performed. The experimental results show that the tomographic imaging with more uniform brightness and clarity for the different depth regions in a thick sample can be achieved by the shift-multiplexing CSD-OCT system. In particular, even while the sample’s depth is beyond the maximum imaging depth of CSD-OCT system, the tomographic imaging of this sample can still be realized by using the shift-multiplexing CSD-OCT method without the need for any replacement of the equipment, such as high spectral capacity grating or high resolution of CCD. The shift-multiplexing CSD-OCT system can perform the imaging with the optimization and less reduction of sensitivity for the deeper detection position in the sample.
Highlights
Optical coherence tomography (OCT) is an advanced optical imaging technique that can be applied in imaging biological tissue due to its noncontact and noninvasive high-resolution capabilities for the semitransparent objects
In our experimental setup of the shiftmultiplexing complex SD-OCT (CSD-OCT) system, the two or three pieces of glass slides are stacked together one upon the other to form the layered structure of front and rear surfaces, which is employed as the target sample
We have proposed a new shift-multiplexing CSD-OCT system, the imaging depth of which is greatly extended by incorporating the shift-multiplexing detection positions with CSD-OCT technique
Summary
Optical coherence tomography (OCT) is an advanced optical imaging technique that can be applied in imaging biological tissue due to its noncontact and noninvasive high-resolution capabilities for the semitransparent objects. Spectral-domain optical coherence tomography (SD-OCT) is an OCT modality based on the Michelson interferometer and the spectrometer. After the object beam is backscattered by a target sample at the end of the sample arm and the reference beam is reflected by a mirror at the end of the reference arm, the same spectral components of two beams will interfere to form the spectral interference fringes containing the depth information of the sample. After having performed the inverse Fourier transform of the spectral interference fringe, the tomographic image with the depth information of sample can be obtained.[1,2,3,4,5,6,7]
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