Abstract
The clinical presentation of severe infection with generalized inflammation is similar, if not identical, to systemic inflammation induced by sterile tissue injury. Novel models and unbiased technologies are urgently needed for biomarker identification and disease profiling in sepsis. Here we briefly review the article of Kamisoglu and colleagues in this issue of Critical Care on comparing metabolomics data from different studies to assess whether responses elicited by endotoxin recapitulate, at least in part, those seen in clinical sepsis.
Highlights
The clinical presentation of severe infection with generalized inflammation is similar, if not identical, to systemic inflammation induced by sterile tissue injury
Correspondence: dossantosc@smh.ca Interdepartmental Division of Critical Care, The Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael’s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada used metabolomics to assess whether responses elicited by endotoxin recapitulate, at least in part, those seen in clinical sepsis [2]
Of all the systems biology disciplines, metabolomics is closest to the phenotype, is profoundly affected by environmental factors, and dynamic changes suggest selection of appropriate time points for biomarker identification will be critical [4, 7]
Summary
The clinical presentation of severe infection with generalized inflammation is similar, if not identical, to systemic inflammation induced by sterile tissue injury. Correspondence: dossantosc@smh.ca Interdepartmental Division of Critical Care, The Keenan Research Centre of the Li Ka Shing Knowledge Institute of St Michael’s Hospital, 30 Bond Street, Toronto, ON M5B 1W8, Canada used metabolomics to assess whether responses elicited by endotoxin recapitulate, at least in part, those seen in clinical sepsis [2]. Metabolic profiling of plasma in both studies was performed using non-targeted mass spectrometry by the same commercial provider.
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