Abstract
Peptic ulcer is a common upper gastrointestinal dis ease that remains a major public health problem. Ga stric ulceration caused by Nonsteroidal Anti-Inflammatory Drugs (NSAID), stress and alcohol are the common causes of ga stric ulcer formation in humans following helicobacter pylori b acterial infection of the stomach. The neurohormone , melatonin was reported to protect against NSAID- and stress-i nduced gastric lesions. We sought to determine whet her melatonin, which is known to have antioxidant effects and indu ces systemic leukocyte mobilization, can protect th e gastric structure from a sterile tissue injury. Equally div ided melatonin or vehicle pre-treated Albino rats (N = 20) were subjected to sterile tissue injury of gastric ulcer ation using hypertonic sodium chloride solution. Me latonin treatment significantly protected the animals from gastric le sions induced by hypertonic salt compared to contro l vehicle-treated animals that show formation of gastric lesions in a ll examined rats. In addition, melatonin treatment significantly increased sterile tissue injury induction of both m ononuclear and polymorphonuclear peripheral blood cells. We conclude that melatonin protects sterile tissue inj ury-induced gastric lesions and augments white bloo d cell populations in response to this type of tissue injury.
Highlights
Gastric ulcer is a necrosis or eroded areas in the mucosa of the stomach due to the deleterious effects of the secreted hydrochloric acid and peptic juice (Yuan et al, 2006; Desia et al, 1997)
Gastric ulceration caused by Nonsteroidal Anti-Inflammatory Drugs (NSAID), stress and alcohol are the common causes of gastric ulcer formation in humans following helicobacter pylori bacterial infection of the stomach
We sought to determine whether melatonin, which is known to have antioxidant effects and induces systemic leukocyte mobilization, can protect the gastric structure from a sterile tissue injury
Summary
Gastric ulcer is a necrosis or eroded areas in the mucosa of the stomach due to the deleterious effects of the secreted hydrochloric acid and peptic juice (Yuan et al, 2006; Desia et al, 1997). The most common cause of gastric ulcer is a curved bacillus bacterium called helicobacter pylori that is commonly found in the stomach (Marshall and Warren, 1984; McColl, 2010; Chey and Wong, 2007). Melatonin is a hormone produced primarily by the pineal gland in the brain. It is derived from the neurotransmitter, serotonin (Cardinali and Pevet, 1998) and plays an important role in controlling the body’s circadian rhythms, sleep-wake cycle (Tan et al, 2003; Silva et al, 2013) and regulates other hormones such as insulin and insulin growth factor receptor and thyroid hormone.
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