Abstract
Nanoscale resolution, high scanning rate, and non-destructive measurement are highly desirable attributes for imagining living cells in fluids. Torsional resonance (TR) mode is a promising approach that can satisfy these requirements. In this study, we have fabricated scanning probes with suitable cantilever designs for use in TR mode in fluids, using computer simulation as an aid in the design and fabrication iterations. Several geometrical parameters of cantilevers were considered and simulated for mechanical properties and dynamic characteristics, and selected designs were fabricated for performance evaluation. The influences of design parameters on scan performance were investigated by statistical analysis. Based on this approach, we designed and fabricated optimal cantilevers that can be operated in TR mode in water with high quality (Q) factor (∼60), high resonance frequency (∼240 kHz), and low spring constant (∼0.14 N m−1). Overall, O-shape cantilevers have demonstrated superior Q factors to typical rectangular shape, A-shape and V-shape designs.
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