Abstract
<i>Background</i>: Sézary syndrome (SS) is a rare erythrodermic and leukemic variant of cutaneous T-cell lymphoma (CTCL) that belongs to the group of non-Hodgkin's lymphomas (NHL) resulting from malignant proliferation of skin-homing T cells. We report through a series of 5 cases, the experience of the hematology laboratory in the diagnosis of the syndrome of Sézary. <i>Methods</i>: This is a retrospective study of 5 cases of Sezary syndrome collected in the dermatology department of Marrakech. <i>Results</i>: five patients were identified with the clinicopathological criteria of SS. At the time of diagnosis, all 5 patients had erythroderma and generalized lymphadenopathy in both superficial and deep stations. The white blood cell count was elevated (>10,000 WBC/mm<sup>3</sup>) in all 5 patients with a mean value of 18,120 WBC/mm<sup>3</sup>. The blood smear showed the presence of 75% (27 G/l) of small to medium-sized cells with a high nucleocytoplasmic ratio and cerebriform nuclei typical of Sezary cells and suggests the diagnosis of SS. <i>Conclusions</i>: The diagnosis of SS remains a challenge in many situations, the pathophysiology and definition of SS have evolved significantly over the past decades.
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