Abstract
To investigate the association of sex hormone-binding globulin (SHBG) levels of early pregnancy with gestational diabetes mellitus (GDM) development. A total of 443 pregnant women during the first trimester (<12 weeks) were enrolled. SHBG levels were measured. SHBG level was lower in women with GDM than in women without GDM (93.9±34.4nmol/l vs 128.1±60.3nmol/l; p =0.001). Among the four quartiles (Q1-Q4) according to SHBG levels, GDM incidences were 17.5, 27.8, 5.1 and 2.6%, respectively. No differences were found between Q1 and Q2, and Q3 and Q4. The risk of developing GDM among women in Q1 + Q2 compared with Q3 + Q4 was 5.7. Decreased SHBG concentrations during the first trimester may predict GDM development.
Published Version
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