Abstract
XYY syndrome is a rare chromosomal disorder that affects males with an incidence of 1 in 1000 males, characterized by having an additional Y chromosome (47,XYY). Although XYY males usually have a normal appearance, and normal sexual development and fertility, they may be taller than average and have a variable risk of cognitive, language, and behavioral deficits. Studies show that 47,XYY syndrome is associated with an increased risk of learning disabilities and delayed development of speech and language skills and motor skills. Most cases of 47,XYY syndrome are not inherited but arise as a random event, mostly by paternal nondisjunction at meiosis II or sometimes by postzygotic mitotic error, resulting in 47,XYY male or mosaic 47,XYY/46,XY, respectively. XYY is not usually transferred from an XYY father to his sons.
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