Abstract
Hybrid sterility genes prevent gene flow between related taxa, making the speciation process irreversible. To understand the genetic control and molecular mechanisms of hybrid sterility in mammals, hybrid sterility genes were mapped in crosses of wild-derived inbred strains originating from house mouse subspecies Mus musculus domesticus, M. m. musculus, and M. m. molossinus and from more distant mouse species M. spretus and M. macedonicus. Hybrid sterility genes in mice obey the same rules (large X-effect and Haldane’s rule) as observed in Drosophila and other species. The first hybrid sterility gene in vertebrates identified at the sequence level is M. m. domesticus hybrid sterility 1 (Hst1) locus that was recognized as ‘PR domain containing 9, Prdm9’, encoding meiosis-specific H3K4 tri-methyltransferase.
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