Severe Type of Minocycline-Induced Hyperpigmentation Mimicking Peripheral Arterial Occlusive Disease in a Bullous Pemphigoid Patient

Wu Wu,Tsai Tsai,Yiang Yiang,Hou Hou,Lin Lin

doi:10.3390/antibiotics8030093

Abstract

Minocycline is a tetracycline group antibiotic that is known to cause significant antibacterial and anti-inflammatory effects. Minocycline has been widely used to treat systemic infection, acne, dermatitis, and rosacea. However, various dose-related side effects of hyperpigmentation in whole body tissues have been reported. Three main types of minocycline-induced hyperpigmentation have been identified. In rare severe hyperpigmentation cases, drug-induced hyperpigmentation can mimic local cellulitis or peripheral arterial occlusive disease (PAOD). These processes require different therapeutic strategies. Therefore, early diagnosis is extremely important for physicians to determine the etiology of the hyperpigmentation, and subsequently discontinue the minocycline if indicated. We describe a rare case presenting a severe form of type III minocycline-induced hyperpigmentation mimicking peripheral arterial occlusive disease in a bullous pemphigoid patient.

Highlights

Minocycline is a highly lipophilic antibiotic in the tetracycline group of antibiotics that exhibits both antibacterial and anti-inflammatory effects [1]
We present a rare case of a patient with severe type minocycline-induced hyperpigmentation, combined with atypical peripheral arterial occlusive disease (PAOD) symptoms
In this we present a rare case of a patient with severe type minocycline-induced hyperpigmentation, combined with atypical PAOD symptoms

Summary

Introduction

Minocycline is a highly lipophilic antibiotic in the tetracycline group of antibiotics that exhibits both antibacterial and anti-inflammatory effects [1]. We present a rare case of a patient with severe type minocycline-induced hyperpigmentation, combined with atypical PAOD symptoms. In this we present a rare case of a patient with severe type minocycline-induced hyperpigmentation, combined with atypical PAOD symptoms. Population,bullous bullous rupture may induce cellulitis or present as a chronic skin ulcer, delaying timely diagnosis. We highlight that minocycline-induced hyperpigmentation can mimic other acute processes, highlight that minocycline-induced hyperpigmentation can mimic other acute processes, confounding confounding diagnosis. This can lead This to thecan persistence of persistence the side effects if minocycline discontinued

Case Presentation

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Discussion

Conclusions