Abstract
Background: SARS-CoV-2 Omicron variant with so far the highest transmissible capability increases the risk of re-infection and vaccine breakthrough infections. Detection of what are the severe spectrums of SARSCoV- 2 Omicron variant-infected pediatric cases was essential in guiding clinical and public health strategies. Data Sources: Original research articles and literature reviews were collected from databases, mainly PubMed. Relevant articles about severe COVID-19 infected pediatric cases and Omicron variant were included. Results: Omicron infected pediatric cases were less severe than previous variant-infected cases, however, because of significantly increased cases, infants and children were hospitalized at a higher number. The severe spectrums of Omicron infected pediatric cases were slightly different from those in the pre- Omicron period. Seizure and croup were two major severe spectrums of SARSCoV- 2 Omicron variant-infected pediatric cases, while MIS-C was less frequent. Even though vaccine breakthrough infection was common, vaccination is effective in preventing hospitalization and critical cases. Conclusions: SARS-CoV-2 Omicron variant-infected pediatric cases shared slightly different severe spectrums with previous variants. Vaccination is strongly recommended for eligible children for preventing hospitalization and critical Covid-19 cases.
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