Abstract
We have recently studied 2 patients with renal disease in whom signs of severe renal irritation developed following fever induced by intravenous typhoid vaccine. Engman and McGarry1briefly describe a patient who developed microscopic hematuria after receiving intravenous typhoid vaccine, and Campbell2reported hematuria in an arthritic patient being treated with nonspecific protein (typhoid) fever therapy. In 1932 Hench3reviewed the usual and unusual reactions of typhoid vaccine protein therapy in a series of 2,500 patients. There were 14 unusual reactions in this series, 2 of whom died with anuria. At necropsy acute diffuse nephritis was found in 1 case and no renal lesion in the other. Our 2 patients had previous renal disease—the nephrotic stage of hemorrhagic Bright's disease in 1, and malignant hypertension in the other—conditions which might be contraindications to foreign protein therapy.4 Because pyrexia induced by injection of foreign protein has been
Published Version
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