Abstract
In the recent past a new drug known as Tofranil * or imipramine hydrochloride has come into use for the treatment of depressive states.1 Chemically it is a drug of the phenothiazine group ( N-γ-dimethyl-aminopropyl-iminodibenzyl-hydrochloride). Pharmacologically it acts as an antidepressant. As the use of this drug became more widespread, reports of toxic side-effects, similar to those of certain antihistamines, began to appear in the literature, although cases of acute poisoning are rare. In June, 1960, we had the opportunity of treating a case of acute imipramine poisoning in an infant of 1½ years. Report of a Case On June 17, 1960, a girl of 1½ years, weighing 10 kg. was admitted to Pediatric Department A of the Asaf Harofe Government Hospital after having one hour previously ingested 15-20 tablets of imipramine, 25 mg. each, which had been prescribed for her mother who was suffering from depression. On admission the child
Published Version
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