Abstract
Four cholera outbreaks were reported in the Central African Republic during 1997–2016. We show that the outbreak isolates were Vibrio cholerae O1 serotype Inaba from 3 seventh pandemic El Tor sublineages originating from West Africa (sublineages T7 and T9) or the African Great Lakes Region (T10).
Highlights
Four cholera outbreaks were reported in the Central African Republic during 1997–2016
The Institut Pasteur de Bangui in Central African Republic (CAR) performed microbial analyses to confirm the causal agent of these outbreaks and identified 30 V. cholerae O1 serotype Inaba isolates collected during 1997–2016 (Appendix 1 Table 1, https://wwwnc. cdc.gov/EID/article/27/1/20-0375-App1.x1sx)
Phylogenetic data showed that the 7PET strains causing the 2011 and 2016 cholera outbreaks in CAR spread from African Great Lakes Region (AGLR) to the western part of the Democratic Republic of the Congo (DRC) and CAR (Figure 2, panel B; Appendix 2 Figure 3)
Summary
*7PET, seventh pandemic Vibrio cholerae O1 El Tor; AMR, antimicrobial resistance; NT, not detected; WT, wild type. The prevalent T10 sublineage has several clades, and the 2011 and 2016 CAR isolates are characterized by multilocus sequence type (ST) 515, a single-locus variant of ST69; ST69 is the predominant ST among 7PET isolates. These isolates have an alteration to the wbeT gene, a 4-nucleotide deletion called B01 (Tables 1, 2), that underly the Inaba serotype. Phylogenetic data showed that the 7PET strains causing the 2011 and 2016 cholera outbreaks in CAR spread from AGLR to the western part of the DRC and CAR (Figure 2, panel B; Appendix 2 Figure 3).
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