Sesquiterpene Lactones and Phenolics from Roots of Leontodon hispidus subsp. hispidus

Abstract

The phytochemical investigation on roots of Leontodon hispidus L. subsp. hispidus, led to the isolation of nine sesquiterpene lactones including two eudesmanolides of santamarine type and three lactucin-like guaianolides together with four known phenolic compounds. The eudesmanolides – santamarine and 11 β,13-dihydrosantamarine, guaianolides – matricarin, deacetylmatricarin and deacetylmatricarin 8- O- β-glucopyranoside, and phenolics – syringaldehyde, 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-1-propanone, syringin and dihydroconiferin were found for the first time in Leontodon.