Abstract
Serum xanthine oxidase (SeXO) determination was performed on the sera of 2000 patients. SeXO elevations of 10 international milliunits (ImU) and above were noted only in acute liver disease. In viral hepatitis or toxic liver injury the magnitude of elevations of SeXO to the upper limit of normal is 50 times greater than the magnitude of elevation of the transaminases above normal. The enzyme level in obstructive or hemolytic jaundice remains normal or slightly elevated, not exceeding 10 lmU/liter. For this reason serum xanthine oxidase determination is valuable in differentiating jaundice due to acute liver disease from that due to obstructive jaundice or hemolysis, as there is almost no overlap in the enzyme values. On the other hand, SeXO determination had no diagnostic or prognostic value in liver cirrhosis, amebic abscess, or hydatid cyst of liver. Significant elevations of SeXO were noted in infectious mononucleosis but in none of the other viral infections studied.
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