Serum Vitamin D Associated with Insulin Secretory Function in Impaired Fasting Glucose Subjects

A K M Shahidur Rahman,Mohammad Ibrahim Ali,Md Arifuzzaman Sohel,Syed Fazlul Islam,Md Kabir Hossain,Farjana Rahman Bhuiyan,Fahad Al Shatil Ashrafee,Rahelee Zinnat

doi:10.4236/jbm.2019.71008

A K M Shahidur Rahman, Mohammad Ibrahim Ali + Show 6 more

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https://doi.org/10.4236/jbm.2019.71008

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Background: Impaired fasting glucose (IFG) is a prediabetic condition and is a high-risk state for developing diabetes and associated complications. The aim of this study was to explore the association of vitamin D with insulin secretory function among the IFG subjects. Materials and Methods: This was a prospective cross-sectional study conducted in the Department of Biochemistry and Cell Biology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh; from June 2016 to May 2017, on forty-six (46) IFG subjects. Serum blood glucose was measured by glucose-oxidase method, Fasting serum lipid profile (Total cholesterol, TG and HDL-c); liver enzyme like alanine aminotransferase (ALT) was measured by enzymatic-colorimetric method; Serum creatinine was measured by colorimetric kinetic method; Serum Insulin and vitamin D [25(OH)D] were measured by ELISA method; insulin secretory capacity (HOMA%B) and insulin sensitivity (HOMA%S) were calculated by Homeostasis Model Assessment (HOMA) using HOMA-CIGMA software. Results: Among 46 IFG subjects, 22 (47.8%) were male and rest 24 (52.2%) were female and their mean age was 40 (±8) years. Mean fasting serum glucose level of the study subjects was 6.33 (±0.23) mmol/l and mean postprandial serum glucose level was 7.23 (±0.41) mmol/l. Mean serum vitamin D level of the study subjects was 26.54 (±8.83) ng/ml. Mean HOMA%S, HOMA%B and HOMA%IR of the total study subjects were 48.34 (±16.70), 102.16 (±23.13) and 2.28 (±0.70) respectively. Insulin secretory capacity (HOMA%B) was significantly higher (p = 0.047) in the subjects having higher vitamin D [25(OH)D level ≥ 20 ng/ml] compared to the subjects having lower vitamin D [25(OH)D levels < 20 ng/ml]. Conclusion: High prevalence of hypovitaminosis D exists among IFG subjects. Vitamin D is associated with insulin secretory function in IFG subjects. Population based prospective studies using larger sample size should be done to confirm the results.

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Serum blood glucose was measured by glucose-oxidase method, Fasting serum lipid profile (Total cholesterol, TG and HDL-c); liver enzyme like alanine aminotransferase (ALT) was measured by enzymatic-colorimetric method; Serum creatinine was measured by colorimetric kinetic method; Serum Insulin and vitamin D [25(OH)D] were measured by ELISA method; insulin secretory capacity (HOMA%B) and insulin sensitivity (HOMA%S) were calculated by Homeostasis Model Assessment (HOMA) using HOMA-CIGMA software
Vitamin D is associated with insulin secretory function in Impaired fasting glucose (IFG) subjects
Impaired fasting glucose (IFG) is the state of an individual whose fasting blood glucose levels are consistently elevated above normal but are not high enough to be considered as having diabetes mellitus

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Introduction

Impaired fasting glucose (IFG) is the state of an individual whose fasting blood glucose levels are consistently elevated above normal but are not high enough to be considered as having diabetes mellitus. Impaired fasting glucose (IFG) [Like impaired glucose tolerance (IGT)] is a prediabetic condition and is a high-risk state for developing diabetes and associated complications [2]. Impaired fasting glucose (IFG) is a prediabetic condition and is a high-risk state for developing diabetes and associated complications. The aim of this study was to explore the association of vitamin D with insulin secretory function among the IFG subjects. Mean serum vitamin D level of the study subjects was 26.54 (±8.83) ng/ml.

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