“SERUM URIC ACID LEVELS WITH INSULIN RESISTANCE IN METABOLIC SYNDROME – A CORRELATION STUDY”

Abstract

Background: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that includes hypertension, central obesity, insulin resistance, and atherogenic dyslipidemia, which is strongly associated with an increased risk for developing diabetes and atherosclerotic and nonatherosclerotic cardiovascular disease (CVD). The increasing prevalence of Obesity across the world will result in an increased prevalence of Metabolic syndrome. However, obesity along with the MetS increases the risk of acquiring Diabetes and cardiovascular diseases (CVD). The prevalence of metabolic syndrome in adults ranges from 20 to 25%, but in those with type 2 diabetes, it can almost always approach 80%. The death rate from high BMI has increased globally by 28.3%. According to the WHO denition of metabolic syndrome, CVD mortality was 2.6 to 3.0 times higher and all-cause death was 1.9 to 2.1 times higher. Elevated uric acid is one of the characteristic signs of metabolic syndrome patients that has been associated with several cardiometabolic risk factors. Despite frequently being thought of as secondary to hyperinsulinemia, current research suggests that uric acid has a primary role in mediating this condition. According to multiple logistic regression analysis, the risk of MetS rose around 2-fold for every 1 mg/dl increase in blood uric acid. This study seeks to determine if insulin resistance and asymptomatic hyperuricemia are related in patients with metabolic syndrome. Aim: To study the correlation of Serum Uric acid levels with Insulin Resistance in Metabolic syndrome. Materials And Methods: A Hospital-based cross-sectional study was conducted in the Department of General Medicine, Santhiram medical college, and the general hospital for six months. A total of 50 cases with asymptomatic Hyperuricemia and insulin resistance who satisfy the criteria for metabolic syndrome and patients that were admitted to the hospital during this period were taken into the study. Results: Out of 50 patients a male preponderance of 72% was found in the study. Subjects in the Metabolic syndrome group had higher BMI, WC, SBP, DBP, FBS, fasting insulin, HOMA-IR index, TG, and HDL levels than the subjects in the non-MetS group. In this study, the mean serum uric acid was signicantly higher in the MetS group than that in the non-MetS group. In the Mets group, the mean value of serum uric acid was 8.1±1.8mg/dl. In the study, 78.6% of women and 75.4% of men had asymptomatic hyperuricemia. In Mets, there was a strong positive correlation between serum uric acid and insulin resistance. Additionally, a favorable association between serum uric acid and several Mets factors such as BMI, waist size, fasting blood sugars, fasting insulin, and HDL was observed. Conclusion: Serum uric acid showed a signicant positive relation with insulin resistance in Mets. There was also a positive correlation noted between serum uric acid and various components of Mets i.e., BMI, waist circumference, fasting blood sugars, fasting insulin, and HDL